Inositol 1,4,5-Trisphosphate Directs Ca21 Flow between Mitochondria and the Endoplasmic/Sarcoplasmic Reticulum: A Role in Regulating Cardiac Autonomic Ca21 Spiking
نویسندگان
چکیده
*Institut National de la Santé et de la Recherche Médicale U-390, CHU Arnaud de Villeneuve, Montpellier, 34295 France; §Centre de Recherches de Biochimie Macromoléculaire, Centre National de la Recherche Scientifique UPR 1086, Montpellier, 34293 France; †Division of Cardiovascular Diseases, Department of Medicine and Molecular Pharmacology, Mayo Clinic, Rochester, Minnesota 55905; and ‡Department of Physiology, Centre Médical Universitaire, Genève, Switzerland
منابع مشابه
Inositol 1,4,5-trisphosphate directs Ca(2+) flow between mitochondria and the Endoplasmic/Sarcoplasmic reticulum: a role in regulating cardiac autonomic Ca(2+) spiking.
The signaling role of the Ca(2+) releaser inositol 1,4, 5-trisphosphate (IP(3)) has been associated with diverse cell functions. Yet, the physiological significance of IP(3) in tissues that feature a ryanodine-sensitive sarcoplasmic reticulum has remained elusive. IP(3) generated by photolysis of caged IP(3) or by purinergic activation of phospholipase Cgamma slowed down or abolished autonomic ...
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تاریخ انتشار 2000